ED therapy has undergone a revolution along with development of PDE5 inhibitors. Tadalafil is the newest and most universal PDE5 inhibitor in clinical solutions of impotency treatment. Morbid physiology of erectile dysfunction has a lot of causes including psychologic, hormonal, neurogenic, drug-addiction- or cavernous-impairment-induced factors. The most widely-spread type of erectile dysfunction is mixture of psychogenic and organic causes.

In 2002, during 97^th annual meeting of American urological association, the first reports about the efficiency and durability of tadalafil action on ED were presented. By the end of 2002, tadalafil was confirmed for application in Europe and in 2003 – in the U.S. The most unique characteristic of this remedy is its long-term elimination half-life (and thus, the duration of its action) – more than seventeen hours in young men and twenty-two hours – in elderly men, whereas elimination half-life of vardenafil and sildenafil is only four hours.

Cialis is also administered in case of prostate adenoma (benign prostatic hyperplasia). It relaxes muscles of prostatic gland and urinary bladder and helps to alleviate such symptoms as frequent urge, painful urination or feeling of incomplete emptying of urinary bladder. Cialis may be used for treatment of people suffering either from erectile dysfunction or from BPH.

Dosages of Generic Cialis

There are the following presentation forms of Cialis:

• Cialis 2,5mg – yellow-orange almond-shaped coated pills.
• Cialis 5mg (for one-day usage) – yellow almond-shaped coated pills.
• Cialis 10mg – yellow almond-shaped film-coated tablets.
• Cialis 20mg – orange almond-shaped coated pills.

There is no form of Cialis jelly. Nevertheless, there is a medication Apcalis-sx which is an analogue of original Cialis. It is issued in the form of jelly for ED therapy. Also, there are generics of Cialis containing 40mg of tadalafil.

Cialis dapoxetine and Cialis forte are remedies for potency boost. The first remedy contains combination of tadalafil 20mg and dapoxetine 60mg. The second drug contains various herbal substances along with zinc oxide, L-arginine, indole-3- carbinol, sephoretin, and vitamins (B6, B9, B12). Thus, tadalafil is absent in Cialis forte. Cialis prices depend on its dosage.

Online Prices

Cialis is an original medication containing tadalafil. It is issued in the form of coated tablets in different dosage. Those who cannot or doesn’t want to by original Cialis due to its high price, can also Cialis generics, for instance generic Cialis Soft. It is completely analogous to licensed Cialis tablets. Generic is produced by Indian company, Centurion Laboratories. Tadalafil content in the generic pills is the same as in the originals. They may only differ in auxiliary agents.

Cialis, Cialis Soft and other Cialis generics may be purchased at Humanity Road for favorable price. Let us consider the price range for Cialis in various doses offered by modern online and offline pharmacies:

• Cialis 2,5mg per pill/per unit: from 3.33 to 9.75 U.S. dollars
• Cialis 5mg per pill/per unit: from 3.00 to 7.46 U.S. dollars
• Cialis 10mg per pill/per unit: from 13.42 to 23.07 U.S. dollars
• Cialis 20mg per pill/per unit: from 10.51 to 23.69 U.S. dollars

It goes without saying that at Humanity Road, you’ll find the best prices for Cialis.

How to Take Generic Cialis

• You shouldn’t administer Cialis more than once a day;
• Always take the medication as per andrologist or sexologist’s prescription;
• Maximally recommended dose of Cialis is 20mg. The tablet is taken before sexual intercourse;
• In case a patient has renal disorders, Cialis recommended dose makes 10mg. This dose may be increased up to 20mg;
• Patients suffering from severe hepatic impairment should take maximally recommended dosage of 10mg;
• If you have hepatic disorder, Cialis recommended dose is 10mg. Patients with severe hepatic impairment must consult his attending doctor;
• Elderly people with diabetes do not require special dosage;
• In case of symptoms connected with benign prostate hyperplasia, medicine’s recommended dose is 5mg. Tablets are taken once a day.
• Dosage correction in patients suffering from hepatic disorders is not required if they do not have severe hepatic failure.
• A tablet is to be drunk with full glass of water.

Tadalafil (Cialis) requires in average two hours in order to achieve maximal concentration in comparison with about 50 minutes for sildenafil and vardenafil. Variations in gastro-intestinal absorption of fatty food are explained by maximal concentration in plasma between three PDE5 inhibitors (Levitra, Viagra and Cialis). While combined intake with fatty food, efficiency of Levitra and Viagra may be decreased, but absorption of Cialis is affected neither by fatty food, nor by alcohol. This unique pharmacokinetic feature of Cialis is a result of slow absorption and more long-term elimination half-life.

A Therapy Course with Cialis

Cialis may be administered with food or alcohol or without them. Nevertheless, alcohol use may impact the ability to achieve erection; therefore, a patient is to avoid the excessive consumption of alcohol. Cialis administration for ED should be performed according to the following rules:

• 10mg or 20mg of the medicine are to be taken not later than 30-60 minutes prior to sexual activity. Required time for the medicine to start working varies in accordance with personal particularities of a person. Some men experience Cialis impact 16 minutes after pill intake. Nevertheless, if a patient uses the remedy for the first time, it is better to take is 1 hour before planned sexual intercourse.
• Cialis is effective within 36 hours. I.e. it is possible to have erection (in case of sexual stimulation) anytime within the course of 36 hours.
• Medications falling into the group of PDE5 inhibitors are designed for constant episodic use. There is no particular therapy course with Cialis, Levitra or Viagra.
• A lot of factors, such as body weight, diseases, intake of other medications may take impact on Cialis dose. In case your attending doctor recommends you dose which is different from the one indicate in this article, follow doctor’s advice.
• In three months after Cialis intake, a patient feels improvement of erectile function manifested by spontaneous erections. In case ED is caused by psychological issues, the improvement is explained by elevated confidence in one’s sexual abilities.
• For the time being, Cialis is the only remedy for impotency, the low dose of which is suitable for daily intake. The initial dose is 2,5mg which may be increased to 5mg.

The decision to use lower doses of such drugs as Levitra or Viagra will be heady, since there are no data available testifying efficiency of such administration.

Effects and Duration

Cialis is used for treatment of erectile dysfunction in men. Its active substance, tadalafil, belongs to the group of PDE5 inhibitors. One Cialis pills contains:

• 5mg of tadalafil;
• Non-medicinal components: croscarmellose sodium, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, ferric oxide red, lactose monohydrate, magnesium stearate, microcrystalline cellulose, lauryl sulfate sodium, talc, titanium dioxide, triacetin.
• This medicine doesn’t contain saccharose, gluten, tartrazine, or other colorants.

Action Profile

Phosphodiesterase type 5 enzyme prevents from erection occurrence by means of splitting of guanosine monophosphate. Guanosine monophosphate is essential for enlargement of penis arteries in order to enable them to fill with blood and receive more oxygen. Phosphodiesterase type 5 inhibitors, such as Cialis prevent PDE5 from splitting guanosine monophosphate. This allows penis to get filled with blood and stay erected long for sexual intercourse.

Cialis undoubtable advantage is the fact that tadalafil remains active in organism much longer than other medications. Viagra and Levitra action lasts around 4-5 hours (sometimes up to 12 hours). As for Cialis, its action time ranges between 24 and 36 hours; therefore, it is sometimes called a medicine for weekends.